SirReal2
- CAS NO.：709002-46-0
- Empirical Formula: C22H20N4OS2
- Molecular Weight: 420.55
- MDL number: MFCD04173051
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:08
What is SirReal2?
Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.
The Uses of SirReal2
SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.
storage
Store at -20°C
Properties of SirReal2
| storage temp. | Store at -20°C |
| solubility | DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml |
| form | A crystalline solid |
| color | Off-white to light yellow |
Safety information for SirReal2
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SirReal2
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