Simeprevir sodium
- CAS NO.：1241946-89-3
- Empirical Formula: C38H47N5O7S2.x(Na)
- Molecular Weight: 773.94
- MDL number: MFCD30724946
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Simeprevir sodium?
Description
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Properties of Simeprevir sodium
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) |
| form | A crystalline solid |
Safety information for Simeprevir sodium
Computed Descriptors for Simeprevir sodium
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