Silicone oil
Synonym(s):PDMS;Polydimethylsiloxane;Silicone oil;Dimethylpolysiloxane;Poly(dimethylsiloxane)
- CAS NO.:63148-62-9
- Empirical Formula: C6H18OSi2
- Molecular Weight: 162.38
- MDL number: MFCD00132673
- EINECS: 613-156-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-15 13:17:26
What is Silicone oil?
Absorption
This drug is not believed to be absorbed when used in quantities from 1-30% .
Toxicity
The minimum lethal oral dose of dimethicone 200 (50 cs), dimethicone 550 (75 cs), dimethicone in rats .
A 76-week dietary toxicity study of a silicone antifoam compound (94% polydimethylsiloxane silicone oil and 6% silicone dioxide) was performed in mice. Three groups were given diet containing 0, 0.25%, or 2.5% of the test article. The dose levels in the treatment groups were estimated to be 580 and 5800 mg/kg/day. Mortality was increased in the 5800 mg/kg/day females. No target organs of toxicity were observed. The no-effect dose was 580 mg/kg/day. This study is of limited usefulness for assessing the toxicity of dimethicones, due to the small number of organs/tissues that were examined .
In one clinical study, 145 subjects were treated with either NYDA (dimethicone )or with a permethrin-based lice product. The number of subjects experiencing any adverse events was similar in both groups. In the NYDA group, 29 adverse events were reported in 25 subjects. All except two adverse events were categorized as being unrelated to the lice treatment (e.g., superficial wound after a fall, otitis externa following swimming in a pool). Two patients in the NYDA group experienced ocular irritation after treatment when the product entered the eyes. The irritation resolved spontaneously in both cases after rinsing the eyes with clean water .
The Uses of Silicone oil
Silicone oil can be used for applications such as: protective coatings for building materials, a cosmetic additive, a dielectric coolant, a lubricant and antiflatulent agent.
Background
Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions .
A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products .
Indications
Dimethicone is a colorless liquid with both cosmetic and therapeutic uses. It is used in topical creams and ointments to help distribute the active ingredients. Dimethicone is used as an anti-foaming agent, a hair and skin conditioner, and in the treatment of head lice and, as an anti-bloating/anti-flatulence agent , .
Pharmacokinetics
This drug acts as a skin protectant by helping to treat and prevent minor skin irritation due to diaper rash and seals out moisture from the diaper area. This drug temporarily protects and helps prevent chafed, chapped, cracked or windburned skin. .
Metabolism
Not Available
Properties of Silicone oil
Melting point: | −59 °C(lit.) |
Boiling point: | 101 °C(lit.) |
Density | 0.963 g/mL at 25 °C |
Flash point: | >270 °C (518 °F) |
storage temp. | 2-8°C |
form | Oily Liquid |
color | Clear colorless |
Odor | Odorless |
Water Solubility | PRACTICALLY INSOLUBLE |
Safety information for Silicone oil
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H225:Flammable liquids H304:Aspiration hazard H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H340:Germ cell mutagenicity H350:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P331:Do NOT induce vomiting. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Silicone oil
Abamectin manufacturer
JSK Chemicals
Covalent Incorporation
Unicorn Petroleum Industries Private Limited
Amit Biotech Private Limited
RioCare India Private Limited
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