Silicone oil

Absorption

This drug is not believed to be absorbed when used in quantities from 1-30% .

Toxicity

The minimum lethal oral dose of dimethicone 200 (50 cs), dimethicone 550 (75 cs), dimethicone in rats .
A 76-week dietary toxicity study of a silicone antifoam compound (94% polydimethylsiloxane silicone oil and 6% silicone dioxide) was performed in mice. Three groups were given diet containing 0, 0.25%, or 2.5% of the test article. The dose levels in the treatment groups were estimated to be 580 and 5800 mg/kg/day. Mortality was increased in the 5800 mg/kg/day females. No target organs of toxicity were observed. The no-effect dose was 580 mg/kg/day. This study is of limited usefulness for assessing the toxicity of dimethicones, due to the small number of organs/tissues that were examined .
In one clinical study, 145 subjects were treated with either NYDA (dimethicone )or with a permethrin-based lice product. The number of subjects experiencing any adverse events was similar in both groups. In the NYDA group, 29 adverse events were reported in 25 subjects. All except two adverse events were categorized as being unrelated to the lice treatment (e.g., superficial wound after a fall, otitis externa following swimming in a pool). Two patients in the NYDA group experienced ocular irritation after treatment when the product entered the eyes. The irritation resolved spontaneously in both cases after rinsing the eyes with clean water .

Chemical properties

viscous colourless liquid

The Uses of Silicone oil

Silicone oil can be used for applications such as: protective coatings for building materials, a cosmetic additive, a dielectric coolant, a lubricant and antiflatulent agent.

The Uses of Silicone oil

(Liquid) Adhesives, lubricants, protective coat- ings, coolants, mold release agents, dielectric fluids, heat transfer, wetting agents and surfac- tants, foam stabilizer for polyurethanes, diffusion pumps, antifoaming agent for liquids, textile fin- ishes, water repellent, weatherproofing concrete, brake fluids, cosmetic items, polishes, foam shields in solar energy collectors, rust preventives. (Resin) Coatings, molding compounds, laminates (with glass cloth), filament winding sealants, room- temperature curing cements, electrical insulation, impregnating electric coils, bonding agent, modifier for alkyd resins, vibration-damping devices. (Elas- tomer, or silicone rubber) Encapsulation of elec- tronic parts; electrical insulation; gaskets; surgical membranes and implants; automobile engine com- ponents; flexible windows for face masks, air locks, etc.; miscellaneous mechanical products.

The Uses of Silicone oil

Silicone oil can be used for a wide range of applications such as: heat transferring medium in chemical and petrochemical industries, a dielectric coolant, protective coatings for building materials, a cosmetic additive.

Background

Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions .
A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products .

Indications

Dimethicone is a colorless liquid with both cosmetic and therapeutic uses. It is used in topical creams and ointments to help distribute the active ingredients. Dimethicone is used as an anti-foaming agent, a hair and skin conditioner, and in the treatment of head lice and, as an anti-bloating/anti-flatulence agent , .

Definition

Any of a large group of siloxane polymers based on a structure consisting of alternate silicon and oxygen atoms with various organic radicals attached to the silicon:

Production Methods

Silicone elastomers are generally prepared from chlorosilanes. The chlorosilanes are hydrolyzed to give hydroxyl compounds that condense to form elastomers. Applications include electrical insulation, gaskets, surgical membranes and implants, and automobile engine components.

General Description

Silicone oil is low viscosity liquid polymerized siloxanes with organic side chains.

Pharmacokinetics

This drug acts as a skin protectant by helping to treat and prevent minor skin irritation due to diaper rash and seals out moisture from the diaper area. This drug temporarily protects and helps prevent chafed, chapped, cracked or windburned skin. .

Safety Profile

An experimental teratogen. Experimental reproductive effects. See also SILICONES.

Metabolism

Not Available