Seneciphylline
Synonym(s):α-Longilobin;3,19-Didehydro-12-hydroxysenecionan-11,16-dione;Jacodine
- CAS NO.:480-81-9
- Empirical Formula: C18H23NO5
- Molecular Weight: 333.38
- MDL number: MFCD00221722
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-21 15:02:05
What is Seneciphylline?
Description
Seneciphylline, a pyrrolizidine alkaloid, one of the main components of Chinese medicine herb Tusanqi, which is a reason of the hepatic sinusoidal obstruction syndrome (HSOS). In addition, experiments on rats have shown that seneciphylline had adverse effects on the development and organic morphodifferentiation of embryos, thus the pregnant people exposed to Hebra may get potential risk on the fetus.
Chemical properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, Derived from the whole plant or root of Gynura segetum (Lour.) Merr (Ju Sanqi).
The Uses of Seneciphylline
Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe. It has the effect of coagulation and hemostasis.
Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.
What are the applications of Application
Seneciphylline is a naturally occurring plant toxin, which is employed to defend the plant against herbivore and insect attacks.
Seneciphylline may be used as an analytical reference standard for the quantification of the analyte in feed samples and traditional Chinese herbal medicines using different chromatography techniques.
Definition
ChEBI: LSM-2853 is a citraconoyl group.
Air & Water Reactions
Reacts slowly with atmospheric oxygen. . Insoluble in water.
Reactivity Profile
SENECIPHYLLIN is readily hydrolyzed with alkali; SENECIPHYLLIN reacts readily with oxidizing agents .
Health Hazard
Seneciphylline and aflatoxin B. may be of greater importance as a cause of human disease than the presently known outbreaks of poisoning would indicate.
SYMPTOMS: Symptoms associated with this compound include abdominal pain, nausea and diarrhea, emaciation, intestinal edema and congestion of the liver. ACUTE/CHRONIC HAZARDS: Very toxic. (NTP, 1992)
Fire Hazard
Flash point data are not available for SENECIPHYLLIN, but SENECIPHYLLIN is probably combustible.
Properties of Seneciphylline
Melting point: | 217°C |
alpha | D -128° (chloroform) |
Boiling point: | 470.34°C (rough estimate) |
Density | 1.2467 (rough estimate) |
refractive index | 1.5740 (estimate) |
storage temp. | -20°C |
solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
pka | 12.43±0.20(Predicted) |
form | Solid |
form | neat |
color | White to off-white |
Stability: | Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas. |
CAS DataBase Reference | 480-81-9 |
IARC | 3 (Vol. 10, Sup 7) 1987 |
EPA Substance Registry System | Seneciphylline (480-81-9) |
Safety information for Seneciphylline
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Seneciphylline
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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