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HomeProduct name listSeneciphylline

Seneciphylline

Synonym(s):α-Longilobin;3,19-Didehydro-12-hydroxysenecionan-11,16-dione;Jacodine

  • CAS NO.:480-81-9
  • Empirical Formula: C18H23NO5
  • Molecular Weight: 333.38
  • MDL number: MFCD00221722
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-21 15:02:05
Seneciphylline Structural

What is Seneciphylline?

Description

Seneciphylline, a pyrrolizidine alkaloid, one of the main components of Chinese medicine herb Tusanqi, which is a reason of the hepatic sinusoidal obstruction syndrome (HSOS). In addition, experiments on rats have shown that seneciphylline had adverse effects on the development and organic morphodifferentiation of embryos, thus the pregnant people exposed to Hebra may get potential risk on the fetus.

Chemical properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, Derived from the whole plant or root of Gynura segetum (Lour.) Merr (Ju Sanqi).

The Uses of Seneciphylline

Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe. It has the effect of coagulation and hemostasis.
Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.

What are the applications of Application

Seneciphylline is a naturally occurring plant toxin, which is employed to defend the plant against herbivore and insect attacks.
Seneciphylline may be used as an analytical reference standard for the quantification of the analyte in feed samples and traditional Chinese herbal medicines using different chromatography techniques.

Definition

ChEBI: LSM-2853 is a citraconoyl group.

Air & Water Reactions

Reacts slowly with atmospheric oxygen. . Insoluble in water.

Reactivity Profile

SENECIPHYLLIN is readily hydrolyzed with alkali; SENECIPHYLLIN reacts readily with oxidizing agents .

Health Hazard

Seneciphylline and aflatoxin B. may be of greater importance as a cause of human disease than the presently known outbreaks of poisoning would indicate.
SYMPTOMS: Symptoms associated with this compound include abdominal pain, nausea and diarrhea, emaciation, intestinal edema and congestion of the liver. ACUTE/CHRONIC HAZARDS: Very toxic. (NTP, 1992)

Fire Hazard

Flash point data are not available for SENECIPHYLLIN, but SENECIPHYLLIN is probably combustible.

Properties of Seneciphylline

Melting point: 217°C
alpha  D -128° (chloroform)
Boiling point: 470.34°C (rough estimate)
Density  1.2467 (rough estimate)
refractive index  1.5740 (estimate)
storage temp.  -20°C
solubility  DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml
pka 12.43±0.20(Predicted)
form  Solid
form  neat
color  White to off-white
Stability: Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas.
CAS DataBase Reference 480-81-9
IARC 3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System Seneciphylline (480-81-9)

Safety information for Seneciphylline

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P262:Do not get in eyes, on skin, or on clothing.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Seneciphylline

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