RETRORSINE
Synonym(s):β-Longilobine;12,18-Dihydroxysenecionan-11,16-dione;Retrorsin;Senecionan-11,16-Dione, 12,18-Dihydroxy- (9CI)
- CAS NO.：480-54-6
- Empirical Formula: C18H25NO6
- Molecular Weight: 351.39
- MDL number: MFCD00870195
- EINECS: 610-403-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is RETRORSINE?
The Uses of RETRORSINE
Retrorsine-D4 is a labelled analogue of Retrorsine (R279000). Retrorsine is a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, ultimately affecting hepatocyte proliferative capacity.
What are the applications of Application
Retrorsine is a cytotoxic pyrrolizidine alkaloid compound
Definition
ChEBI: Retrorsine is a macrolide.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.
Properties of RETRORSINE
| Melting point: | 208-211 °C (lit.) |
| Boiling point: | 485.2°C (rough estimate) |
| alpha | D18 -17.6° (c = 1.99 in ethanol) |
| Density | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| form | neat |
| pka | 12.00±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| Merck | 13,8253 |
| CAS DataBase Reference | 480-54-6 |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Retrorsine (480-54-6) |
Safety information for RETRORSINE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for RETRORSINE
| InChIKey | BCJMNZRQJAVDLD-VMOBWIEOSA-N |
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