SCH 58261

CAS NO.：160098-96-4
Empirical Formula: C18H15N7O
Molecular Weight: 345.36
MDL number: MFCD00933778
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is SCH 58261?

The Uses of SCH 58261

SCH 58261 is a potent and selective A2A adenosine receptor antagonist.

What are the applications of Application

SCH 58261 is a potent and highly selective Adenosine A2A-R competitive antagonist

Definition

ChEBI: LSM-3822 is a member of triazolopyrimidines.

Biological Activity

Potent and selective A 2A adenosine receptor competitive antagonist (K i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A 1 , A 2B and A 3 receptors, respectively.

Biochem/physiol Actions

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

storage

Store at RT

Properties of SCH 58261

Melting point:	223 °C
Density	1.54±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: >10 mg/mL, soluble
form	solid
pka	2.78±0.30(Predicted)
color	off-white

Safety information for SCH 58261

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.