SCH 58261
- CAS NO.：160098-96-4
- Empirical Formula: C18H15N7O
- Molecular Weight: 345.36
- MDL number: MFCD00933778
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is SCH 58261?
The Uses of SCH 58261
SCH 58261 is a potent and selective A2A adenosine receptor antagonist.
What are the applications of Application
SCH 58261 is a potent and highly selective Adenosine A2A-R competitive antagonist
Definition
ChEBI: LSM-3822 is a member of triazolopyrimidines.
Biological Activity
Potent and selective A 2A adenosine receptor competitive antagonist (K i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A 1 , A 2B and A 3 receptors, respectively.
Biochem/physiol Actions
SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.
storage
Store at RT
Properties of SCH 58261
| Melting point: | 223 °C |
| Density | 1.54±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: >10 mg/mL, soluble |
| form | solid |
| pka | 2.78±0.30(Predicted) |
| color | off-white |
Safety information for SCH 58261
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SCH 58261
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