SCEPTRIN
- CAS NO.:79703-25-6
- Empirical Formula: C22H26Br2Cl2N10O2
- Molecular Weight: 693.22
- MDL number: MFCD03095571
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-10 08:28:03
What is SCEPTRIN?
Description
Sceptrin, an alkaloid isolated from marine sponges such as Agelas conifer, has an unusual structure with a core cyclobutane ring. In 2008, A. D. Rodríguez (University of Puerto Rico, San Juan), M. J. Lear (National University of Singapore), and J. J. La Clair (Xenobe Research Institute, San Diego) showed that sceptrin co-immunoprecipitates with MreB, an actin-like protein derived from Escherichia coli. This work was performed before sceptrin’s structure was known; the same researchers later established the structure.
Two years later, K. Vuori and colleagues at the Burnham Institute for Medical Research and the Scripps Research Institute (both in La Jolla, CA) reported that sceptrin inhibits cell motility in several cancer cell lines. It is not toxic to mice at concentrations twice those required for maximal inhibition.
In an interesting twist, C. Chen (University of Texas Southwestern Medical Center, Dallas), P. S. Baran (Scripps Research Institute), and A. L. Rheingold (University of California, San Diego) found in 2014 that sceptrin and two related sponge alkaloids don’t all have the same chirality pattern. One analogue, ageliferin, matches sceptrin’s chirality, whereas another alkaloid, massadine, has different absolute stereochemistry. It’s not clear why the parent sponge has varying biosynthesis sequences.
The Uses of SCEPTRIN
Sceptrin dihydrochloride is an antibiotic which inhibits cell motility.
What are the applications of Application
Sceptrin dihydrochloride is an antibiotic which inhibits cell motility
Properties of SCEPTRIN
storage temp. | −20°C |
form | Amorphous powder. |
Safety information for SCEPTRIN
Computed Descriptors for SCEPTRIN
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%View Details
99903-60-3 -
88491-46-7 98%View Details
88491-46-7 -
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%View Details
25408-95-1 -
2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%View Details
1805639-70-6 -
1784294-80-9 98%View Details
1784294-80-9 -
Lithium ClavulanateView Details
61177-44-4