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HomeProduct name listSC 57461A

SC 57461A

Synonym(s):N-Methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl β-alanine hydrochloride;SC-57461 hydrochloride

SC 57461A Structural

What is SC 57461A?

Description

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.

Chemical properties

White Solid

The Uses of SC 57461A

SC 57461A is a potent and selective inhibitor of LTA4.

The Uses of SC 57461A

A potent and selective orally active leukotriene A4 hydrolase inhibitor.

What are the applications of Application

SC 57461A is a potent and selective inhibitor of LTA4 hydrolase

Biological Activity

Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active.

Properties of SC 57461A

Melting point: 163-165°C
storage temp.  Desiccate at +4°C
solubility  DMSO: >5mg/mL
form  powder
color  white to off-white

Safety information for SC 57461A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for SC 57461A

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