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HomeProduct name listSB 218795

SB 218795

SB 218795 Structural

What is SB 218795?

The Uses of SB 218795

SB 218795 is an NK3 receptor antagonist.

What are the applications of Application

SB 218795 is a potent and selective NK3 antagonist

Definition

ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.

Biological Activity

Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.

Properties of SB 218795

Boiling point: 623.7±55.0 °C(Predicted)
Density  1.237±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 40 mg/mL, soluble
form  solid
pka 11.41±0.46(Predicted)
color  white

Safety information for SB 218795

Computed Descriptors for SB 218795

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