sandramycin
- CAS NO.:100940-65-6
- Empirical Formula: C60H76N12O16
- Molecular Weight: 1221.32
- MDL number: MFCD09752757
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is sandramycin?
The Uses of sandramycin
Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycin class produced by Kribbella sp.. Sandramycin has potent antitumour and antibacterial activity, and is thought to act by bis-intercalation of DNA.
The Uses of sandramycin
Sandramycin is a potent antibacterial agent.
What are the applications of Application
Sandramycin is a potent antibacterial agent
Biological Activity
sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a nocardioides sp [1].sandramycin is an antitumor antibiotic. sandramycin was closely related to the cyclic depsipeptides luzopeptins a, b, c and d. sandramycin exhibited strong inhibition to the gram-positive organisms bacillus subtilis, staphylococcus aureus and streptococcusfaecalis. its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin a [1]. sandramycin was also a bifunctional dna intercalator that strongly binds dna and forms crosslinks between dna molecules [2].in transplantable mouse leukemia p388, sandramycin was moderately active with values comparable to those for luzopeptin a. injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1].
References
[1]. matson ja, bush ja. sandramycin, a novel antitumor antibiotic produced by a nocardioides sp. production, isolation, characterization and biological properties. j antibiot (tokyo). 1989 dec;42(12):1763-7.
[2]. boger dl, saionz kw. dna binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. bioorg med chem. 1999 feb;7(2):315-21.
Properties of sandramycin
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | solid |
Safety information for sandramycin
Computed Descriptors for sandramycin
New Products
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