SALICYLIDENE SALICYLHYDRAZIDE

Synonym(s):2-Hydroxybenzylidene 2-hydroxybenzhydrazide;NSC 87864;SCS

CAS NO.：3232-36-8
Empirical Formula: C14H12N2O3
Molecular Weight: 256.26
MDL number: MFCD00043494
EINECS: 221-773-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

SALICYLIDENE SALICYLHYDRAZIDE Structural

What is SALICYLIDENE SALICYLHYDRAZIDE?

The Uses of SALICYLIDENE SALICYLHYDRAZIDE

SCS is a selective inhibitor of β1-containing GABAA receptors.

What are the applications of Application

SCS is potent and selective partial inhibitor of β1-containing GABAA receptors

Definition

ChEBI: 2-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide is a member of salicylamides.

Biological Activity

Potent and selective partial inhibitor of β 1-containing GABA A receptors (IC 50 values are 4.5, 5.3 and 7.9 nM at α 2 β 1 γ 1 θ , α 2 β 1 γ 1 and α 2 β 1 γ 2s GABA A receptors respectively). May bind allosterically to a novel site on GABA A receptor.

Properties of SALICYLIDENE SALICYLHYDRAZIDE

Melting point:	280-284°C
storage temp.	Store at RT
solubility	DMSO: ~20 mg/mL
form	solid
color	off-white
BRN	2944701
CAS DataBase Reference	3232-36-8(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazide (3232-36-8)

Safety information for SALICYLIDENE SALICYLHYDRAZIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.