(S)-(+)-Glycidyl Phthalimide

Synonym(s):(S)-N-Glycidylphthalimide

CAS NO.：161596-47-0
Empirical Formula: C11H9NO3
Molecular Weight: 203.19
MDL number: MFCD04973350
EINECS: 454-720-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is (S)-(+)-Glycidyl Phthalimide?

Chemical properties

White powder

The Uses of (S)-(+)-Glycidyl Phthalimide

N-(S)-Glycidylphthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500).

Synthesis

Phthalimide and (S)-1-substituent propylene oxide are used as raw materials, a reaction occurs under the action of a catalyst to generate 2-((S)-3-substituent-2-hydroxypropyl isodihydroindole-1,3-dione, and finally (S)-glycidyl phthalimide is generated by means of a ring-closure reaction.
(S)-( )-GLYCIDYL PHTHALIMIDE

Preperation

Phthalimide and (S)-1-substituent propylene oxide are used as raw materials, and a reaction occurs under the action of a catalyst to generate 2-((S)-3-substituent-2-hydroxypropyl isodihydroindole-1,3-dione, and finally (S)-glycidyl phthalimide is generated using a ring-closure reaction.

Properties of (S)-(+)-Glycidyl Phthalimide

Melting point:	102 °C
Boiling point:	347.4±15.0 °C(Predicted)
Density	1.446±0.06 g/cm3(Predicted)
vapor pressure	0.001-2.17Pa at 25-90.25℃
refractive index	10 ° (C=2.2, CHCl3)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	-2.24±0.20(Predicted)
form	Solid
color	White

Safety information for (S)-(+)-Glycidyl Phthalimide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Health Hazard GHS08
GHS Hazard Statements	H318:Serious eye damage/eye irritation H341:Germ cell mutagenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..…