S(-)-BAY K 8644

Synonym(s):S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

CAS NO.：98625-26-4
Empirical Formula: C16H15F3N2O4
Molecular Weight: 356.3
MDL number: MFCD00153769
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is S(-)-BAY K 8644?

The Uses of S(-)-BAY K 8644

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats.

What are the applications of Application

BAY K 8644, S(?)- is an L-type Ca2+-channel activator

Definition

ChEBI: (S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644.

General Description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺?channel activator. It is an enantiomer of Bay K 8644.

Biological Activity

L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ).

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

Storage

Store at +4°C

Properties of S(-)-BAY K 8644

storage temp.	2-8°C
solubility	H₂O: slightly soluble
form	solid
color	yellow

Safety information for S(-)-BAY K 8644

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.