S(-)-BAY K 8644
Synonym(s):S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
- CAS NO.:98625-26-4
- Empirical Formula: C16H15F3N2O4
- Molecular Weight: 356.3
- MDL number: MFCD00153769
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is S(-)-BAY K 8644?
The Uses of S(-)-BAY K 8644
(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats.
What are the applications of Application
BAY K 8644, S(?)- is an L-type Ca2+-channel activator
Definition
ChEBI: (S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644.
General Description
(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+?channel activator. It is an enantiomer of Bay K 8644.
Biological Activity
L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ).
Biochem/physiol Actions
(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.
storage
Store at +4°C
Properties of S(-)-BAY K 8644
storage temp. | 2-8°C |
solubility | H2O: slightly soluble |
form | solid |
color | yellow |
Safety information for S(-)-BAY K 8644
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for S(-)-BAY K 8644
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