S-(4-NITROBENZYL)-6-THIOINOSINE
Synonym(s):6-[(4-Nitrobenzyl)thio]-9-β-D -ribofuranosylpurine;NBMPR;NBTI
- CAS NO.:38048-32-7
- Empirical Formula: C17H17N5O6S
- Molecular Weight: 419.41
- MDL number: MFCD00005745
- EINECS: 253-753-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is S-(4-NITROBENZYL)-6-THIOINOSINE?
Chemical properties
Off-White Solid
The Uses of S-(4-NITROBENZYL)-6-THIOINOSINE
S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
The Uses of S-(4-NITROBENZYL)-6-THIOINOSINE
It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio
What are the applications of Application
S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is an inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties
Definition
ChEBI: NBMPR is a purine nucleoside.
General Description
S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.
Biological Activity
Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
storage
Store at +4°C
Properties of S-(4-NITROBENZYL)-6-THIOINOSINE
Melting point: | 187-190 °C(lit.) |
Boiling point: | 770.2±70.0 °C(Predicted) |
Density | 1.3904 (rough estimate) |
refractive index | 1.6460 (estimate) |
storage temp. | 2-8°C |
solubility | 0.1 M HCl: slightly soluble |
form | solid |
pka | 13.08±0.70(Predicted) |
color | white |
CAS DataBase Reference | 38048-32-7(CAS DataBase Reference) |
Safety information for S-(4-NITROBENZYL)-6-THIOINOSINE
Computed Descriptors for S-(4-NITROBENZYL)-6-THIOINOSINE
New Products
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