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HomeProduct name listS-(4-NITROBENZYL)-6-THIOINOSINE

S-(4-NITROBENZYL)-6-THIOINOSINE

Synonym(s):6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine;NBMPR;NBTI

  • CAS NO.:38048-32-7
  • Empirical Formula: C17H17N5O6S
  • Molecular Weight: 419.41
  • MDL number: MFCD00005745
  • EINECS: 253-753-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
S-(4-NITROBENZYL)-6-THIOINOSINE Structural

What is S-(4-NITROBENZYL)-6-THIOINOSINE?

Chemical properties

Off-White Solid

The Uses of S-(4-NITROBENZYL)-6-THIOINOSINE

S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.

The Uses of S-(4-NITROBENZYL)-6-THIOINOSINE

It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio

What are the applications of Application

S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is an inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties

Definition

ChEBI: NBMPR is a purine nucleoside.

General Description

S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

Biological Activity

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Biochem/physiol Actions

Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.

storage

Store at +4°C

Properties of S-(4-NITROBENZYL)-6-THIOINOSINE

Melting point: 187-190 °C(lit.)
Boiling point: 770.2±70.0 °C(Predicted)
Density  1.3904 (rough estimate)
refractive index  1.6460 (estimate)
storage temp.  2-8°C
solubility  0.1 M HCl: slightly soluble
form  solid
pka 13.08±0.70(Predicted)
color  white
CAS DataBase Reference 38048-32-7(CAS DataBase Reference)

Safety information for S-(4-NITROBENZYL)-6-THIOINOSINE

Computed Descriptors for S-(4-NITROBENZYL)-6-THIOINOSINE

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