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HomeProduct name list(S)-3,5-DIHYDROXYPHENYLGLYCINE

(S)-3,5-DIHYDROXYPHENYLGLYCINE

Synonym(s):S-DHPG

  • CAS NO.:162870-29-3
  • Empirical Formula: C8H9NO4
  • Molecular Weight: 183.16
  • MDL number: MFCD00673763
  • EINECS: 2017-001-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
(S)-3,5-DIHYDROXYPHENYLGLYCINE Structural

What is (S)-3,5-DIHYDROXYPHENYLGLYCINE?

The Uses of (S)-3,5-DIHYDROXYPHENYLGLYCINE

(S)-3,5-Dihydroxyphenylglycine hydrate has been used:

  • as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
  • in ACSF for DHPG stimulation
  • to inject into basolateral amygdala to study its effect on memory expression

The Uses of (S)-3,5-DIHYDROXYPHENYLGLYCINE

(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.

What are the applications of Application

(S)-3,5-DHPG is a selective agonist of group I mGluR

Definition

ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.

Biological Activity

Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

Biochem/physiol Actions

(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.

storage

-20°C (desiccate). Protect from light.

Properties of (S)-3,5-DIHYDROXYPHENYLGLYCINE

Melting point: >207°C (dec.)
Boiling point: 448.8±33.0 °C(Predicted)
Density  1.550±0.06 g/cm3(Predicted)
storage temp.  −20°C
solubility  Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, H
form  solid
pka 1.77±0.10(Predicted)
color  white
Water Solubility  Soluble to 50 mM in water
Stability: Hygroscopic

Safety information for (S)-3,5-DIHYDROXYPHENYLGLYCINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for (S)-3,5-DIHYDROXYPHENYLGLYCINE

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