(S)-3,5-DIHYDROXYPHENYLGLYCINE
Synonym(s):S-DHPG
- CAS NO.:162870-29-3
- Empirical Formula: C8H9NO4
- Molecular Weight: 183.16
- MDL number: MFCD00673763
- EINECS: 2017-001-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is (S)-3,5-DIHYDROXYPHENYLGLYCINE?
The Uses of (S)-3,5-DIHYDROXYPHENYLGLYCINE
(S)-3,5-Dihydroxyphenylglycine hydrate has been used:
- as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
- in ACSF for DHPG stimulation
- to inject into basolateral amygdala to study its effect on memory expression
The Uses of (S)-3,5-DIHYDROXYPHENYLGLYCINE
(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.
What are the applications of Application
(S)-3,5-DHPG is a selective agonist of group I mGluR
Definition
ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.
Biological Activity
Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
Biochem/physiol Actions
(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.
storage
-20°C (desiccate). Protect from light.
Properties of (S)-3,5-DIHYDROXYPHENYLGLYCINE
Melting point: | >207°C (dec.) |
Boiling point: | 448.8±33.0 °C(Predicted) |
Density | 1.550±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, H |
form | solid |
pka | 1.77±0.10(Predicted) |
color | white |
Water Solubility | Soluble to 50 mM in water |
Stability: | Hygroscopic |
Safety information for (S)-3,5-DIHYDROXYPHENYLGLYCINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-3,5-DIHYDROXYPHENYLGLYCINE
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