(S)-1-Boc-2-(Hydroxymethyl)piperazine
- CAS NO.:1030377-21-9
- Empirical Formula: C10H20N2O3
- Molecular Weight: 216.28
- MDL number: MFCD07772093
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-19 09:29:34
What is (S)-1-Boc-2-(Hydroxymethyl)piperazine?
The Uses of (S)-1-Boc-2-(Hydroxymethyl)piperazine
(S)-1-Boc-2-hydroxymethyl-piperazine is a heterocyclic building block used in synthetic chemistry.
Reactions
(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.
Synthesis
To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.
Properties of (S)-1-Boc-2-(Hydroxymethyl)piperazine
Boiling point: | 324℃ |
Density | 1.085 |
Flash point: | 150℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
pka | 14.97±0.10(Predicted) |
Safety information for (S)-1-Boc-2-(Hydroxymethyl)piperazine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-1-Boc-2-(Hydroxymethyl)piperazine
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