(S)-1-Boc-2-(Hydroxymethyl)piperazine

CAS NO.：1030377-21-9
Empirical Formula: C10H20N2O3
Molecular Weight: 216.28
MDL number: MFCD07772093
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-15 15:57:13

What is (S)-1-Boc-2-(Hydroxymethyl)piperazine?

The Uses of (S)-1-Boc-2-(Hydroxymethyl)piperazine

(S)-1-Boc-2-hydroxymethyl-piperazine is a heterocyclic building block used in synthetic chemistry.

Reactions

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.

Synthesis

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.
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Properties of (S)-1-Boc-2-(Hydroxymethyl)piperazine

Boiling point:	324℃
Density	1.085
Flash point:	150℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	14.97±0.10(Predicted)

Safety information for (S)-1-Boc-2-(Hydroxymethyl)piperazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.