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HomeProduct name list(R)-1-N-Boc-2-(hydroxymethyl)piperazine

(R)-1-N-Boc-2-(hydroxymethyl)piperazine

(R)-1-N-Boc-2-(hydroxymethyl)piperazine Structural

What is (R)-1-N-Boc-2-(hydroxymethyl)piperazine?

The Uses of (R)-1-N-Boc-2-(hydroxymethyl)piperazine

(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

Synthesis

Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.
(R)-1-N-Boc-2-(hydroxymethyl)piperazine

Properties of (R)-1-N-Boc-2-(hydroxymethyl)piperazine

Boiling point: 324.0±17.0 °C(Predicted)
Density  1.085±0.06 g/cm3(Predicted)
storage temp.  2-8°C(protect from light)
pka 14.97±0.10(Predicted)

Safety information for (R)-1-N-Boc-2-(hydroxymethyl)piperazine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for (R)-1-N-Boc-2-(hydroxymethyl)piperazine

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