RS 23597-190 HYDROCHLORIDE

Synonym(s):3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;-190;-190

CAS NO.：149719-06-2
Empirical Formula: C16H24Cl2N2O3
Molecular Weight: 363.28
MDL number: MFCD00672672
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 20:41:25

What is RS 23597-190 HYDROCHLORIDE?

The Uses of RS 23597-190 HYDROCHLORIDE

RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.

What are the applications of Application

RS 23597-190 hydrochloride is a selective and competitive SR-4 antagonist

Biological Activity

A high affinity, selective competitive antagonist at 5-HT 4 receptors.

Biochem/physiol Actions

RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).

storage

Store at RT

Properties of RS 23597-190 HYDROCHLORIDE

storage temp.	Sealed in dry,2-8°C
solubility	Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM)
form	Powder
color	White to off-white
Water Solubility	Soluble to 100 mM in water