rosoxacin

CAS NO.：40034-42-2
Empirical Formula: C17H14N2O3
Molecular Weight: 294.3
MDL number: MFCD00057294
EINECS: 254-758-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 08:26:49

What is rosoxacin?

The Uses of rosoxacin

Antibacterial.

Indications

For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.

Background

Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.

Definition

ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. An antibacterial drug, active against Neisseria gonorrhoeae, it has be n used for treating urinary tract infections and certain sexually transmitted diseases.

brand name

Roxadyl (Sterling Winthrop).

Pharmacokinetics

Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Pharmacokinetics

A single oral dose of 300 mg produces a mean peak plasma concentration of 4–5 mg/L at about 2–4 h, with an apparent elimination half-life of about 6 h. Elimination in the urine is partly as the N-oxide metabolite and the glucuronide of this metabolite.
Side effects are those common to quinolones, notably gastrointestinal tract and CNS disturbances. About 50% of patients treated with single oral doses of 100–400 mg developed dizziness, drowsiness, altered visual perception and other CNS effects.
It is effective as single-dose treatment of patients with urethral and anorectal gonorrhea, but coexistent C. trachomatis infection is not eliminated from most patients and postgonococcal urethritis develops in up to 30%.

Metabolism

Not Available

Properties of rosoxacin

Melting point:	290°
Boiling point:	500.8±50.0 °C(Predicted)
Density	1.317±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF (Very Slightly)
form	Solid
pka	6.48±0.41(Predicted)
color	Light Beige to Beige

Safety information for rosoxacin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.