ROSE BENGAL
Synonym(s):Rose Bengal;Acid Red 94;Rose Bengal sodium salt;Aniline Rose;Bengal Rose B sodium salt
- CAS NO.:632-68-8
- Empirical Formula: C20H5Cl4I4KO5
- Molecular Weight: 1013.77
- MDL number: MFCD00068422
- EINECS: 211-182-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is ROSE BENGAL?
Absorption
No information available.
Toxicity
Rose Bengal induces cytotoxic effects in different cell lines .
Background
Rose bengal is a pink stain derived as an analogue of fluorescein. Its disodium salt in ophthalmic solutions has been used as a diagnostic agent in suspected damage to conjunctival and corneal cells. It is also used in laboratory settings, including the preparation of Foraminifera for microscopic analysis and suppression of bacterial growth in several microbiological media. A direct cytotoxic effect of Rose bengal on microorganisms and cancer cells has been observed, questioning its potential antitumor actions via intralesional injections. The clinical applications of rose bengal as injectable formulation under the name PV-10 in melanoma, breast cancer and skin conditions such as eczema and psoriasis are being investigated in clinical trials.
Indications
Indicated as a diagnostic agent in routine ocular examinations or when superficial conjunctiva or corneal tissue change is suspected, and as an aid in the diagnosis of keratoconjunctivitis sicca, keratitis, abrasions or corrosions as well as the detection of foreign bodies.
Preparation
Resorcinol and 4,5,6,7-Tetrachloroisobenzofuran-1,3-dione condensation, The resulting 2-(1,2,7,8-Tetrachloro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid?tetraiodide, potassium or sodium salt is then transformed into.
Pharmacokinetics
Rose bengal is a staining agent that visualized ocular surfaces of both diseased and dead cells in vivo . It has also shown to stain healthy cultured cells, including rabbit corneal epithelial cells, in a rapid, dose-dependent manner . Various studies demonstrate the cytotoxic effects of rose bengal in different cell cultures, including smooth-muscle cells from human intestine, endothelial cells from bovinepulmonary artery, rabbit Tenon fibro-blasts, and rabbit and human corneal epithelial cells . Cellular morphological changes such as detachment, separation, loss of motility and disruption, in addition to swelling, intracytoplasmic vacuole formation and lysis have been manifested with the treatment of rose bengal , indicating that rose Bengal is not a vital dye.
Metabolism
No information available.
Properties and Applications
bright blue light pink. Soluble in water for blu-ray red, no fluorescence. The strong sulfuric acid for brown, after diluted pink precipitation.
Standard | Light Fastness | Soaping | Persperation Fastness | Oxygen bleaching | Fastness to seawater | |||
Fading | Stain | Fading | Stain | Fading | Stain | |||
ISO | 1 | 4 | 4 | 1 | 5 | |||
AATCC | 1 | 4 | 4 | 3-4 |
Properties of ROSE BENGAL
form | Powder |
color | Dark red to rust |
EPA Substance Registry System | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, dipotassium salt (632-68-8) |
Safety information for ROSE BENGAL
Computed Descriptors for ROSE BENGAL
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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