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HomeProduct name listROR gamma-t-IN-1

ROR gamma-t-IN-1

  • CAS NO.:1426802-50-7
  • Empirical Formula: C23H18Cl2F3NO4S
  • Molecular Weight: 532.36
  • MDL number: MFCD28902182
  • Update Date: 2024-11-19 15:53:33
ROR gamma-t-IN-1 Structural

What is ROR gamma-t-IN-1?

Description

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

Properties of ROR gamma-t-IN-1

Boiling point: 617.1±55.0 °C(Predicted)
Density  1.434±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM)
form  A crystalline solid
pka 12.33±0.70(Predicted)
color  White to off-white

Safety information for ROR gamma-t-IN-1

Computed Descriptors for ROR gamma-t-IN-1

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