ROR gamma-t-IN-1
- CAS NO.：1426802-50-7
- Empirical Formula: C23H18Cl2F3NO4S
- Molecular Weight: 532.36
- MDL number: MFCD28902182
- Update Date: 2024-11-14 14:09:35
What is ROR gamma-t-IN-1?
Description
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.
Properties of ROR gamma-t-IN-1
| Boiling point: | 617.1±55.0 °C(Predicted) |
| Density | 1.434±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM) DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.33±0.70(Predicted) |
| color | White to off-white |
Safety information for ROR gamma-t-IN-1
Computed Descriptors for ROR gamma-t-IN-1
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) Diclofenac Sodium SODIUM VALPROATE Racecadotril XANTHAN GUM 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid](https://img.chemicalbook.in/CAS/20180713/GIF/890842-28-1.gif)
You may like
-
RORγt Inverse Agonist II, GSK805 CAS 1426802-50-7View Details
1426802-50-7 -
3-Bromo-2-hydroxybenzeneacetic acid 98%View Details
88491-46-7 -
1805639-70-6 98%View Details
1805639-70-6 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
25408-95-1 98%View Details
25408-95-1 -
1-(3-Chloro-2-hydroxyphenyl)-2-propanone 98%View Details
1784294-80-9 -
99903-60-3 98%View Details
99903-60-3 -
5-Fluoro-2-iodo-3-methylaniline 1823368-42-8 98%View Details
1823368-42-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.