Ripasudil Hydrochloride
Synonym(s):4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride;K-115 hydrochloride
- CAS NO.：223644-02-8
- Empirical Formula: C15H19ClFN3O2S
- Molecular Weight: 359.8466632
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-03 08:28:36
What is Ripasudil Hydrochloride?
The Uses of Ripasudil Hydrochloride
Ripasudil Hydrochloride Dihydrate is a derivative of fasudil and a rho kinase inhibitor (1,2). It is used for the treatment of glaucoma and ocular hypertension.
The Uses of Ripasudil Hydrochloride
Ripasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing.
Properties of Ripasudil Hydrochloride
| Melting point: | 258-259 °C (decomp) |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Sparingly) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for Ripasudil Hydrochloride
Computed Descriptors for Ripasudil Hydrochloride
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