Rimonabant hydrochloride

Synonym(s):5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide hydrochloride;SR141716;SR-141716;SR141716A;SR-141716A

CAS NO.：158681-13-1
Empirical Formula: C22H21Cl3N4O.ClH
Molecular Weight: 500.25
MDL number: MFCD00934884
EINECS: 233-720-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-07 18:29:35

What is Rimonabant hydrochloride?

Chemical properties

White to Off-White Crystalline Solid

The Uses of Rimonabant hydrochloride

The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists

The Uses of Rimonabant hydrochloride

A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.

The Uses of Rimonabant hydrochloride

Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:

to study its effects on protein synthesis in C2C12 myotubes
to analyze its effects on human astroglia
in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity

What are the applications of Application

Rimonabant Hydrochloride is a CB1 (cannabinoid receptor 1) antagonist

Hazard

A poison.

Biochem/physiol Actions

Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation.

storage

Desiccate at RT

Properties of Rimonabant hydrochloride

Melting point:	230-240°C
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
color	white to beige
CAS DataBase Reference	158681-13-1(CAS DataBase Reference)

Safety information for Rimonabant hydrochloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.