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HomeProduct name listRIBOSTAMYCIN SULFATE SALT

RIBOSTAMYCIN SULFATE SALT

  • CAS NO.:25546-65-0
  • Empirical Formula: C17H34N4O10
  • Molecular Weight: 454.47
  • MDL number: MFCD00057496
  • EINECS: 247-091-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-03-19 15:37:50
RIBOSTAMYCIN SULFATE SALT Structural

What is RIBOSTAMYCIN SULFATE SALT?

Description

Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections.

Background

Ribostamycin is an aminoglycoside antibiotic isolated from Streptomyces ribosidificus listed as one of the World Health Organization's critically important antimicrobials.

Definition

ChEBI: An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attache at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).

Mechanism of action

Ribostamycin (SF-733) is produced by Streptomyces ribosidificus. The free base is crystallized from methanol solution. The structure has been determined by chemical methods and total synthesis has been undertaken .

Metabolism

Not Available

Properties of RIBOSTAMYCIN SULFATE SALT

Melting point: 192-195°; mp 175-180° (dec)
Boiling point: 561.28°C (rough estimate)
alpha  D23 +42°
Density  1.1751 (rough estimate)
refractive index  1.6700 (estimate)
storage temp.  2-8°C
pka 7.70(at 25℃)

Safety information for RIBOSTAMYCIN SULFATE SALT

Computed Descriptors for RIBOSTAMYCIN SULFATE SALT

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