Raubasine
Synonym(s):δ-Yohimbine;Py-Tetrahydroserpentine;Raubasine
- CAS NO.:483-04-5
- Empirical Formula: C21H24N2O3
- Molecular Weight: 352.43
- MDL number: MFCD00042748
- EINECS: 207-589-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is Raubasine?
Description
Vinca rosea L. yields this alkaloid which crystallizes as colourless needles from MeOH. The base is laevorotatory having a specific rotation of [α]D_620 (MeOH) and forms a crystalline hydrochloride, m.p. 281-3°e. The structure given above has been elucidated from chemical and spectroscopic data.
The Uses of Raubasine
Antihypertensive, anti-ischemic (cerebral and peripheral)
The Uses of Raubasine
Antihypertensive, anti-ischemic.
Definition
ChEBI: Ajmalicine is a monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist and a vasodilator agent. It is a monoterpenoid indole alkaloid, a methyl ester and an organic heteropentacyclic compound. It is a conjugate base of an ajmalicine(1+).
Purification Methods
It crystallises from MeOH, EtOH or EtOAc. [Beilstein 27 III/IV 7927.]
References
Janot, Le Men, Cornpt. Rend., 243, 1786 (1956) Shamma, Moss, J. Arner. Chern. Soc., 83, 5038 (1961) Abdurakhsimova, Yuldashev, Yunusov, Khirn. Prir. Soedin., 1,224 (1965)
Properties of Raubasine
Melting point: | 258°C (rough estimate) |
Boiling point: | 486.04°C (rough estimate) |
alpha | D20 -60° (c = 0.5 in chloroform); D20 -45° (c = 0.5 in pyridine); D20 -39° (c = 0.25 in methanol) |
Density | 1.1823 (rough estimate) |
refractive index | 1.6500 (estimate) |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
form | Solid |
pka | pK1:10.55(+1) (25°C) |
color | Pale Yellow |
optical activity | [α]/D -65±3°, c = 1 in chloroform |
Water Solubility | insoluble in water |
BRN | 97268 |
NIST Chemistry Reference | Ajmalicine(483-04-5) |
Safety information for Raubasine
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H300:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Raubasine
Abamectin manufacturer
Kothari Phytochemicals and Industries Ltd.
Indo Phytochem Pharmaceuticals
Sarv Bio Labs Pvt Ltd
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