RAC 8-HYDROXY EFAVIRENZ
- CAS NO.：205754-33-2
- Empirical Formula: C14H9ClF3NO3
- Molecular Weight: 331.67
- MDL number: MFCD09840726
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 20:41:25
What is RAC 8-HYDROXY EFAVIRENZ?
Description
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.
Chemical properties
Off-White Solid
The Uses of RAC 8-HYDROXY EFAVIRENZ
A labellebed metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor
The Uses of RAC 8-HYDROXY EFAVIRENZ
8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.
Properties of RAC 8-HYDROXY EFAVIRENZ
| Melting point: | 144-154°C |
| Boiling point: | 373.6±42.0 °C(Predicted) |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Acetonitrile: soluble; DMSO: soluble; Methanol: soluble |
| form | A solid |
| pka | 7.18±0.40(Predicted) |
| color | White to off-white |
Safety information for RAC 8-HYDROXY EFAVIRENZ
Computed Descriptors for RAC 8-HYDROXY EFAVIRENZ
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