(R)-(+)-THALIDOMIDE
Synonym(s):R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- CAS NO.:2614-06-4
- Empirical Formula: C13H10N2O4
- Molecular Weight: 258.23
- MDL number: MFCD00210220
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 09:30:57
What is (R)-(+)-THALIDOMIDE?
Chemical properties
Needles
The Uses of (R)-(+)-THALIDOMIDE
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative
The Uses of (R)-(+)-THALIDOMIDE
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.
The Uses of (R)-(+)-THALIDOMIDE
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
What are the applications of Application
(R)-(+)-Thalidomide is one isomer of the antiangiogenic Thalidomide
Definition
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.
Properties of (R)-(+)-THALIDOMIDE
Melting point: | 269-271°C |
Boiling point: | 401.48°C (rough estimate) |
Density | 1.2944 (rough estimate) |
refractive index | 1.5300 (estimate) |
storage temp. | -20°C Freezer |
solubility | DMSO: soluble |
form | solid |
pka | 10.70±0.40(Predicted) |
color | white |
Safety information for (R)-(+)-THALIDOMIDE
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H360:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for (R)-(+)-THALIDOMIDE
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2,2-diethoxyethanethioamide Tubulysin F Tubulysin A 3-N-BOC-(S)-AMINO BUTYRONITRILE 1-(1,1-Difluoroethyl)-2-fluorobenzene 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROPIPERIDINE 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Calcium Sodium Phosphosilicate IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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