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HomeProduct name list(R)-(+)-THALIDOMIDE

(R)-(+)-THALIDOMIDE

Synonym(s):R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

(R)-(+)-THALIDOMIDE Structural

What is (R)-(+)-THALIDOMIDE?

Chemical properties

Needles

The Uses of (R)-(+)-THALIDOMIDE

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative

The Uses of (R)-(+)-THALIDOMIDE

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.

The Uses of (R)-(+)-THALIDOMIDE

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

What are the applications of Application

(R)-(+)-Thalidomide is one isomer of the antiangiogenic Thalidomide

Definition

ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

Properties of (R)-(+)-THALIDOMIDE

Melting point: 269-271°C
Boiling point: 401.48°C (rough estimate)
Density  1.2944 (rough estimate)
refractive index  1.5300 (estimate)
storage temp.  -20°C Freezer
solubility  DMSO: soluble
form  solid
pka 10.70±0.40(Predicted)
color  white

Safety information for (R)-(+)-THALIDOMIDE

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for (R)-(+)-THALIDOMIDE

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