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HomeProduct name list(R)-PK11195

(R)-PK11195

Synonym(s):1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide

(R)-PK11195 Structural

What is (R)-PK11195?

Chemical properties

Yellowish oil

The Uses of (R)-PK11195

PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.

Definition

ChEBI: PK-11195 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine It has a role as an antineoplastic agent. It is a member of isoquinolines, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Properties of (R)-PK11195

CAS DataBase Reference 85340-56-3

Safety information for (R)-PK11195

Computed Descriptors for (R)-PK11195

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