(R)-PK11195
Synonym(s):1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
- CAS NO.：85340-56-3
- Empirical Formula: C21H21ClN2O
- Molecular Weight: 352.86
- MDL number: MFCD02102012
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
What is (R)-PK11195?
Chemical properties
Yellowish oil
The Uses of (R)-PK11195
PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.
Definition
ChEBI: PK-11195 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine It has a role as an antineoplastic agent. It is a member of isoquinolines, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.
Properties of (R)-PK11195
| CAS DataBase Reference | 85340-56-3 |
Safety information for (R)-PK11195
Computed Descriptors for (R)-PK11195
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