(R)-N-Glycidylphthalimide

Synonym(s):(R)-N-Glycidylphthalimide

CAS NO.：181140-34-1
Empirical Formula: C11H9NO3
Molecular Weight: 203.19
MDL number: MFCD04973349
EINECS: 629-091-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-20 16:43:00

What is (R)-N-Glycidylphthalimide?

Chemical properties

White solid

The Uses of (R)-N-Glycidylphthalimide

(R)-N-Glycidylphthalimide is a reagent used for the simultaneous preparation of amino alcohol solvating agents as well as preparation of orally available anticoagulants.

The Uses of (R)-N-Glycidylphthalimide

(R)-(-)-N-(2,3-Epoxypropyl)phthalimide may be used in the preparation of the following potential chiral solvating agents:

2-[(2R)-2-hydroxy-3-[[(1R)-2-hydroxy-1-phenyl-ethyl]amino]propyl] isoindoline-1,3-dione
2-[(2R)-2-hydroxy-3-[[(1R,2S)-2-hydroxyindan-1-yl]amino]propyl]isoindoline-1,3-dione
2-[(2R)-2-hydroxy-3-[[(1R)-1-(hydroxymethyl)-propyl]amino]propyl] isoindoline-1,3-dione
2-[(2R)-2-hydroxy-3-[[(1S)-1-phenylethyl]-amino]propyl]isoindoline-1,3-dione

It may also be used in the synthesis of 2-((5R)-2-oxo-5-oxazolidinyl) methyl)-1H-isoindole-1,3 (2H)-dione.

Properties of (R)-N-Glycidylphthalimide

Melting point:	101 °C
Boiling point:	347.4±15.0 °C(Predicted)
Density	1.446±0.06 g/cm3 (20 ºC 760 Torr)
refractive index	-10 ° (C=2.2, CHCl3)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-2.24±0.20(Predicted)
color	White

Safety information for (R)-N-Glycidylphthalimide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.