(R)-1-Boc-3-Aminopiperidine

Synonym(s):(R)-1-Boc-3-piperidinamine;tert-Butyl (R)-3-amino-1-piperidinecarboxylate

CAS NO.：188111-79-7
Empirical Formula: C10H20N2O2
Molecular Weight: 200.28
MDL number: MFCD03094717
EINECS: 628-472-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-07-03 15:15:11

What is (R)-1-Boc-3-Aminopiperidine?

Chemical properties

Yellow liquid

The Uses of (R)-1-Boc-3-Aminopiperidine

(R)-(-)-3-Amino-1-Boc-piperidine is used as an intermediate in the manufacture of various substances such as pharmaceuticals.

The Uses of (R)-1-Boc-3-Aminopiperidine

(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.

General Description

(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.

Properties of (R)-1-Boc-3-Aminopiperidine

Boiling point:	277.3±33.0 °C(Predicted)
alpha	28.5 º (c=1, DMF)
Density	1.041±0.06 g/cm3(Predicted)
refractive index	1.4730
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), DMF (Slightly), DMSO (Slightly)
form	Liquid
pka	10.35±0.20(Predicted)
color	Colorless to pale yellow
optical activity	[α]/D -28.5±2°, c = 1 in DMF
Water Solubility	Immiscible with water.
Sensitive	Moisture Sensitive
InChI	InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
CAS DataBase Reference	188111-79-7(CAS DataBase Reference)

Safety information for (R)-1-Boc-3-Aminopiperidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.