Quinine sulfate dihydrate

CAS NO.：6119-70-6
Empirical Formula: C20H26N2O6S
Molecular Weight: 422.5
MDL number: MFCD00150790
EINECS: 639-128-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 16:21:11

What is Quinine sulfate dihydrate?

Chemical properties

White or almost white, crystalline powder or fine, colourless needles.

Chemical properties

Quinine sulfate is odorless and has a persistent, very bitter taste. It darkens on exposure to light. Its saturated solution is neutral or alkaline to litmus.

The Uses of Quinine sulfate dihydrate

Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).

The Uses of Quinine sulfate dihydrate

Quinine sulfate is an antimalarial agent also used as antipyreticum and in liquids (tonic etc.).

The Uses of Quinine sulfate dihydrate

Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

What are the applications of Application

Quinine hemisulfate is a Stereoisomer of quinidine

brand name

Coco-Quinine (Lilly).

Synthesis

Manufacture of quinine by extraction from cinchona bark and subsequent purification and synthesis to quinine sulfate

Properties of Quinine sulfate dihydrate

Melting point:	~225 °C (dec.)(lit.)
alpha	-245 º (c=2, 0.1M HCl)
FEMA	2977 \| QUININE SULFATE
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Soluble in a mixture of chloroform and absolute alcohol (2:1).
form	Crystalline Powder
color	Light yellow or beige to brown
Odor	odorless
Water Solubility	0.12 g/100 mL (20 ºC)
Sensitive	Light Sensitive
Merck	14,8061
BRN	6113937
Stability:	Stable. Incompatible with strong oxidizing agents, alkalies, ammonia, strong bases, iodine.
CAS DataBase Reference	6119-70-6(CAS DataBase Reference)

Safety information for Quinine sulfate dihydrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.