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HomeProduct name listQUINETHAZONE (1.5 G)

QUINETHAZONE (1.5 G)

Synonym(s):7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide

  • CAS NO.:73-49-4
  • Empirical Formula: C10H12ClN3O3S
  • Molecular Weight: 289.73858
  • MDL number: MFCD00867329
  • EINECS: 2008017
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
QUINETHAZONE (1.5 G) Structural

What is QUINETHAZONE (1.5 G)?

Chemical properties

white powder

The Uses of QUINETHAZONE (1.5 G)

Quinethazone is a thiazide diuretic used to treat hypertension.

Indications

Used to treat hypertension.

Background

Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.

Definition

ChEBI: Quinethazone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension. It has a role as an antihypertensive agent and a diuretic.

brand name

Hydromox (Lederle).

General Description

Fibrous crystals or white powder.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for QUINETHAZONE (1.5 G) are not available; however, QUINETHAZONE (1.5 G) is probably combustible.

Pharmacokinetics

Quinethazone is a thiazide diuretic used to treat hypertension. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Metabolism

Not Available

Properties of QUINETHAZONE (1.5 G)

Melting point: 250-252°
Density  1.4208 (rough estimate)
refractive index  1.6300 (estimate)
storage temp.  Refrigerator
solubility  DMSO (Slightly), Methanol (Slightly, Sonicated)
form  Solid
pka pKa 9.3 (Uncertain);10.7 (Uncertain)
color  Pale Beige to Brown
Water Solubility  0.15g/L(25 ºC)
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
EPA Substance Registry System Quinethazone (73-49-4)

Safety information for QUINETHAZONE (1.5 G)

Computed Descriptors for QUINETHAZONE (1.5 G)

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