QUINETHAZONE (1.5 G)
Synonym(s):7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide
- CAS NO.:73-49-4
- Empirical Formula: C10H12ClN3O3S
- Molecular Weight: 289.73858
- MDL number: MFCD00867329
- EINECS: 2008017
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is QUINETHAZONE (1.5 G)?
Chemical properties
white powder
The Uses of QUINETHAZONE (1.5 G)
Quinethazone is a thiazide diuretic used to treat hypertension.
Indications
Used to treat hypertension.
Background
Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.
Definition
ChEBI: Quinethazone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension. It has a role as an antihypertensive agent and a diuretic.
brand name
Hydromox (Lederle).
General Description
Fibrous crystals or white powder.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for QUINETHAZONE (1.5 G) are not available; however, QUINETHAZONE (1.5 G) is probably combustible.
Pharmacokinetics
Quinethazone is a thiazide diuretic used to treat hypertension. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Metabolism
Not Available
Properties of QUINETHAZONE (1.5 G)
Melting point: | 250-252° |
Density | 1.4208 (rough estimate) |
refractive index | 1.6300 (estimate) |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | Solid |
pka | pKa 9.3 (Uncertain);10.7 (Uncertain) |
color | Pale Beige to Brown |
Water Solubility | 0.15g/L(25 ºC) |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
EPA Substance Registry System | Quinethazone (73-49-4) |
Safety information for QUINETHAZONE (1.5 G)
Computed Descriptors for QUINETHAZONE (1.5 G)
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