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HomeProduct name listquinaldopeptin

quinaldopeptin

quinaldopeptin Structural

What is quinaldopeptin?

Description

Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).

The Uses of quinaldopeptin

Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. Quinaldopeptin is related to the luzopeptins and sandramycin.

The Uses of quinaldopeptin

Quinaldopeptin is a bis-intercalating cyclic peptide antibiotic.

What are the applications of Application

Quinaldopeptin is a bis-intercalating cyclic peptide antibiotic

Properties of quinaldopeptin

Density  1.45±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: soluble; DMSO: soluble; Ethanol: slightly soluble; Methanol: slightly soluble
form  Yellow powder.
pka 6.91±0.40(Predicted)

Safety information for quinaldopeptin

Computed Descriptors for quinaldopeptin

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