quinaldopeptin
- CAS NO.:130743-07-6
- Empirical Formula: C62H78N14O14
- Molecular Weight: 1243.38
- MDL number: MFCD08061897
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is quinaldopeptin?
Description
Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).
The Uses of quinaldopeptin
Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. Quinaldopeptin is related to the luzopeptins and sandramycin.
The Uses of quinaldopeptin
Quinaldopeptin is a bis-intercalating cyclic peptide antibiotic.
What are the applications of Application
Quinaldopeptin is a bis-intercalating cyclic peptide antibiotic
Properties of quinaldopeptin
Density | 1.45±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: soluble; DMSO: soluble; Ethanol: slightly soluble; Methanol: slightly soluble |
form | Yellow powder. |
pka | 6.91±0.40(Predicted) |
Safety information for quinaldopeptin
Computed Descriptors for quinaldopeptin
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