PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE

CAS NO.：207671-42-9
Empirical Formula: C7H7NO5
Molecular Weight: 185.13
MDL number: MFCD00149413
EINECS: 629-130-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE?

Description

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC₅₀ = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.

Properties of PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE

Melting point:	246-248 °C (dec.)(lit.)
storage temp.	Store at -20°C
solubility	DMSO: 1.4 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form	A crystalline solid
BRN	131631

Safety information for PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.