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HomeProduct name listPYRIDINE-2-CARBOXAMIDE

PYRIDINE-2-CARBOXAMIDE

Synonym(s):2-Pyridinecarboxamide;Picolinamide

  • CAS NO.:1452-77-3
  • Empirical Formula: C6H6N2O
  • Molecular Weight: 122.12
  • MDL number: MFCD00023483
  • EINECS: 215-921-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:09:03
PYRIDINE-2-CARBOXAMIDE Structural

What is PYRIDINE-2-CARBOXAMIDE?

Chemical properties

White to off-white solid

The Uses of PYRIDINE-2-CARBOXAMIDE

A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.

The Uses of PYRIDINE-2-CARBOXAMIDE

Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO4.

What are the applications of Application

Picolinamide is a bidentate ligand

Definition

ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.

Biological Activity

picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.

Biochem/physiol Actions

Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.

in vitro

the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].

in vivo

picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].

References

[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.

Properties of PYRIDINE-2-CARBOXAMIDE

Melting point: 110 °C (dec.)(lit.)
Boiling point: 143 °C / 20mmHg
Density  1.2236 (rough estimate)
refractive index  1.5350 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
pka pK1: 2.10(+1) (20°C)
form  Solid
color  White to Off-White
BRN  109617
CAS DataBase Reference 1452-77-3(CAS DataBase Reference)
EPA Substance Registry System 2-Pyridinecarboxamide (1452-77-3)

Safety information for PYRIDINE-2-CARBOXAMIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PYRIDINE-2-CARBOXAMIDE

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