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HomeProduct name listPyrazofurin

Pyrazofurin

Synonym(s):4-Hydroxy-5-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide;Pirazofurin;Pyrazomycin

Pyrazofurin Structural

What is Pyrazofurin?

The Uses of Pyrazofurin

Geldanamycin (G304500) derivative.

Definition

ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.

Biochem/physiol Actions

Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.

Enzyme inhibitor

This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.

Properties of Pyrazofurin

Boiling point: 584.4±50.0 °C(Predicted)
Density  1.785±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO, Water (Slightly)
pka 7.17±0.50(Predicted)
form  powder
color  white to light brown
optical activity [α]/D -49 to -39°, c = 0.5 in H2O
Stability: Hygroscopic

Safety information for Pyrazofurin

Computed Descriptors for Pyrazofurin

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