Pyrazofurin
Synonym(s):4-Hydroxy-5-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide;Pirazofurin;Pyrazomycin
- CAS NO.：30868-30-5
- Empirical Formula: C9H13N3O6
- Molecular Weight: 259.22
- MDL number: MFCD07995040
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Pyrazofurin?
The Uses of Pyrazofurin
Geldanamycin (G304500) derivative.
Definition
ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.
Biochem/physiol Actions
Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.
Enzyme inhibitor
This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.
Properties of Pyrazofurin
| Boiling point: | 584.4±50.0 °C(Predicted) |
| Density | 1.785±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO, Water (Slightly) |
| pka | 7.17±0.50(Predicted) |
| form | powder |
| color | white to light brown |
| optical activity | [α]/D -49 to -39°, c = 0.5 in H2O |
| Stability: | Hygroscopic |
Safety information for Pyrazofurin
Computed Descriptors for Pyrazofurin
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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