Pyrazofurin
Synonym(s):4-Hydroxy-5-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide;Pirazofurin;Pyrazomycin
- CAS NO.:30868-30-5
- Empirical Formula: C9H13N3O6
- Molecular Weight: 259.22
- MDL number: MFCD07995040
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Pyrazofurin?
The Uses of Pyrazofurin
Geldanamycin (G304500) derivative.
Definition
ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.
Biochem/physiol Actions
Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.
Enzyme inhibitor
This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.
Properties of Pyrazofurin
Boiling point: | 584.4±50.0 °C(Predicted) |
Density | 1.785±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO, Water (Slightly) |
pka | 7.17±0.50(Predicted) |
form | powder |
color | white to light brown |
optical activity | [α]/D -49 to -39°, c = 0.5 in H2O |
Stability: | Hygroscopic |
Safety information for Pyrazofurin
Computed Descriptors for Pyrazofurin
New Products
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