Punicalagin

Description

Punicalagin (65995-63-3) is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2?It has been shown to reduce high glucose-induced neural tube defects by blocking cellular stress and caspase activation.3?Punicalagin prevented high-fat diet induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage via AMPK mediated modulation of mitochondria and phase II enzymes.4

The Uses of Punicalagin

Punicalagin is a natural polyphenolic compound extracted from the fruit of Pomegranate and acts as an effective anti-inflammatory and anti-oxidant.

Definition

ChEBI: Punicalagin is a tannin.

What are the applications of Application

Punicalagin is an ellagitannin reported to produce antioxidant, anti-inflammatory, and anticancer effects.

References

1) Seeram?et al. (2005),?In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice; J. Nutr. Biochem.,?16?360 2) Adams?et al. (2006),?Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells; J. Agric. Food Chem.,?54?980 3) Zhong?et al. (2015),?Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects; Biochem. Biophys. Res. Commun.,?467?179 4) Cao?et al. (2015),?Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation; Sci. Rep.,?5?14014