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HomeProduct name listPunicalagin

Punicalagin

Punicalagin Structural

What is Punicalagin?

Description

Punicalagin (65995-63-3) is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2?It has been shown to reduce high glucose-induced neural tube defects by blocking cellular stress and caspase activation.3?Punicalagin prevented high-fat diet induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage via AMPK mediated modulation of mitochondria and phase II enzymes.4

The Uses of Punicalagin

Punicalagin is a natural polyphenolic compound extracted from the fruit of Pomegranate and acts as an effective anti-inflammatory and anti-oxidant.

What are the applications of Application

Punicalagin is an ellagitannin reported to produce antioxidant, anti-inflammatory, and anticancer effects.

Definition

ChEBI: Punicalagin is a tannin.

References

1) Seeram?et al. (2005),?In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice; J. Nutr. Biochem.,?16?360 2) Adams?et al. (2006),?Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells; J. Agric. Food Chem.,?54?980 3) Zhong?et al. (2015),?Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects; Biochem. Biophys. Res. Commun.,?467?179 4) Cao?et al. (2015),?Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation; Sci. Rep.,?5?14014

Properties of Punicalagin

Melting point: >155°C (dec.)
Density  2.076±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  methanol: soluble5mg/mL, clear
pka 1.92±0.60(Predicted)
form  powder
color  faint yellow to dark yellow
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.

Safety information for Punicalagin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Punicalagin

InChIKey ZJVUMAFASBFUBG-UYMKNUMKSA-N

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