PSI-7977-13C-d3
- CAS NO.：2070009-25-3
- Empirical Formula: C2113CH26D3FN3O9P
- Molecular Weight: 0
- Update Date: 2023-05-21 10:59:17
What is PSI-7977-13C-d3?
Description
PSI-7977-13C-d3 is intended for use as an internal standard for the quantification of PSI-7977 by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.
The Uses of PSI-7977-13C-d3
PSI-7977-13CD3 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Properties of PSI-7977-13C-d3
| storage temp. | Store at -20°C |
| solubility | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.2 mg/ml |
| form | A solid |
Safety information for PSI-7977-13C-d3
Computed Descriptors for PSI-7977-13C-d3
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