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HomeProduct name listPROTAC PARP1 degrader

PROTAC PARP1 degrader

  • CAS NO.:2369022-68-2
  • Empirical Formula: C58H63Cl2N11O10
  • Molecular Weight: 1145.09
  • MDL number: MFCD32705102
  • Update Date: 2024-07-02 08:55:09
PROTAC PARP1 degrader Structural

What is PROTAC PARP1 degrader?

Biological Activity

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

References

[1]. Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.

Properties of PROTAC PARP1 degrader

Density  1.39±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
form  Solid
pka 14.32±0.46(Predicted)
color  White to off-white

Safety information for PROTAC PARP1 degrader

Computed Descriptors for PROTAC PARP1 degrader

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