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HomeProduct name listPROTAC KRASG12C Degrader-LC-2

PROTAC KRASG12C Degrader-LC-2

  • CAS NO.:2502156-03-6
  • Empirical Formula: C59H71ClFN11O7S
  • Molecular Weight: 1132.78
  • MDL number: MFCD32857122
  • Update Date: 2024-07-02 08:55:17

What is PROTAC KRASG12C Degrader-LC-2?

Description

LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterzygous KRAS G12C cell lines.

storage

Store at -20°C

Properties of PROTAC KRASG12C Degrader-LC-2

Density  1.297±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C)
form  Solid
pka 14.07±0.40(Predicted)
color  Off-white to brown

Safety information for PROTAC KRASG12C Degrader-LC-2

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PROTAC KRASG12C Degrader-LC-2

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