propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
- CAS NO.:1421-14-3
- Empirical Formula: C18H27NO5
- Molecular Weight: 337.41
- EINECS: 215-822-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:51
What is propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate?
Chemical properties
yellow oil bp0.7 210-212°C soluble in alcohol, chloroform, essentially water insoluble anasthetic Epontol (Bayer) Sombrevin
The Uses of propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
Anesthetic (intravenous).
The Uses of propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
Sombrevin, is an ultra short-acting phenylacetate general anesthetic.
Definition
ChEBI: Propanidid is a member of methoxybenzenes.
brand name
Epontol (Farbenfabriken Bayer A.G., Germany).
Clinical Use
Propanidid is used as a very short- to shortacting intravenous anesthetic for minor surgery and gynecology. It is characterized by rapid onset of and quick recovery from anesthesia, producing surgical anesthesia for 3 – 4 min. Repeated injections can be used to prolong the anesthesia. Postanesthetic sleep does not occur because the propyl ester is hydrolyzed rapidly in the patient to form inactive 3-methoxy-4- (N,N-diethylcarbamoylmethoxy)phenylacetic acid. After 20 – 30 min the patients generally are completely responsive .
Synthesis
Propanidid , propyl 3-
methoxy-4-(N,N-diethylcarbamoylmethoxy)-
phenylacetate, is a colorless to pale
yellowish water-insoluble oil. It is prepared
from the propyl ester of sodium homovanillic
acid and N,N-diethylchloroacetamide .
Properties of propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
Boiling point: | bp0.7 210-212° |
Density | 1.2043 (rough estimate) |
refractive index | 1.5000 (estimate) |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Ethyl Acetate (Slightly) |
form | Oil |
color | Pale Yellow to Yellow |
EPA Substance Registry System | Propanidid (1421-14-3) |
Safety information for propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
Computed Descriptors for propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
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