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HomeProduct name listPropargyl-PEG8-NHS ester

Propargyl-PEG8-NHS ester

  • CAS NO.:2182601-74-5
  • Empirical Formula: C24H39NO12
  • Molecular Weight: 533.57
  • MDL number: MFCD31536764
  • Update Date: 2024-10-28 16:48:35
Propargyl-PEG8-NHS ester Structural

What is Propargyl-PEG8-NHS ester?

Description

Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.

Biological Activity

Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of Propargyl-PEG8-NHS ester

Boiling point: 593.4±60.0 °C(Predicted)
Density  1.21±0.1 g/cm3(Predicted)
solubility  Soluble in DCM
form  Viscous Liquid
color  Colorless to light yellow

Safety information for Propargyl-PEG8-NHS ester

Computed Descriptors for Propargyl-PEG8-NHS ester

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