Propargyl-PEG8-NHS ester
- CAS NO.：2182601-74-5
- Empirical Formula: C24H39NO12
- Molecular Weight: 533.57
- MDL number: MFCD31536764
- Update Date: 2024-10-28 16:48:35
What is Propargyl-PEG8-NHS ester?
Description
Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.
Biological Activity
Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Propargyl-PEG8-NHS ester
| Boiling point: | 593.4±60.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| solubility | Soluble in DCM |
| form | Viscous Liquid |
| color | Colorless to light yellow |
Safety information for Propargyl-PEG8-NHS ester
Computed Descriptors for Propargyl-PEG8-NHS ester
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