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HomeProduct name listPropargyl-PEG2-acid

Propargyl-PEG2-acid

  • CAS NO.:1859379-85-3
  • Empirical Formula: C8H12O4
  • Molecular Weight: 172.18
  • MDL number: MFCD29764323
  • Update Date: 2024-10-23 13:36:13
Propargyl-PEG2-acid Structural

What is Propargyl-PEG2-acid?

Description

Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage.

The Uses of Propargyl-PEG2-acid

Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Properties of Propargyl-PEG2-acid

storage temp.  -20°C
solubility  DMSO: 250 mg/mL (1451.97 mM)
form  Liquid
color  Colorless to light yellow

Safety information for Propargyl-PEG2-acid

Computed Descriptors for Propargyl-PEG2-acid

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