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HomeProduct name listPROFOXYDIM-LITHIUM

PROFOXYDIM-LITHIUM

Synonym(s):β-ARK1;ADRBK1;BARK1;Clefoxydim lithium salt;FLJ16718

PROFOXYDIM-LITHIUM Structural

What is PROFOXYDIM-LITHIUM?

The Uses of PROFOXYDIM-LITHIUM

Profoxydim Lithium Salt is a salt of Profoxydim (139001-49-3) and an herbicide.

Definition

ChEBI: Profoxydim is a cyclic ketone that is 3-hydroxycyclohex-2-en-1-one substituted by a N-[2-(4-chlorophenoxy)propoxy]butanimidoyl group at position 2 and by a thian-3-yl group at position 5. It is a herbicide used for the control of grass weeds in rice. It has a role as a herbicide and an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor. It is an oxime O-ether, a member of monochlorobenzenes, an aromatic ether, an enol, an organosulfur heterocyclic compound and a cyclic ketone.

General Description

G-protein-coupled receptor kinase 2 (GRK2), which is officially known as adrenergic, beta, receptor kinase 1 (ADRBK1), gene codes for a 689 amino acid protein, that is of 79.573kDa. This gene has 12 catalytic region subdomains. GRK2 is expressed in the vascular endothelium, arterial smooth muscle, myocardium, kidney and in the renal proximal tubule. It is mapped to human chromosome 11q13.

Biochem/physiol Actions

G-protein-coupled receptor kinase 2 (GRK2) or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2. After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity. G-protein-coupled receptor kinase 2 (GRK2) controls several intracellular mechanisms. It helps to maintain the structure and activities of the heart. Hence it participates in several cardiovascular diseases. GRK2 also modulates ion and fluid transport and eventually, blood pressure. It increases the synthesis of mitochondrial superoxide and reduces oxygen utilization and ATP synthesis. This protein serves as a major onco-modulator.

Properties of PROFOXYDIM-LITHIUM

Melting point: <25 °C
Boiling point: 597.2±60.0 °C(Predicted)
Density  1.26±0.1 g/cm3(Predicted)
storage temp.  -70°C
solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  neat
pka 4.25±0.25(Predicted)
color  White to Off-White
Stability: Hygroscopic, Unstable in Solution
EPA Substance Registry System Profoxydim (139001-49-3)

Safety information for PROFOXYDIM-LITHIUM

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H351:Carcinogenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Computed Descriptors for PROFOXYDIM-LITHIUM

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