PPQ-102

Synonym(s):;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem

CAS NO.：931706-15-9
Empirical Formula: C26H22N4O3
Molecular Weight: 438.48
MDL number: MFCD14824240
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is PPQ-102?

What are the applications of Application

PPQ-102 is a cell-permeable inhibitor of CFTR- mediated chloride currents

General Description

A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.

storage

Store at -20°C

Properties of PPQ-102

Melting point:	>300℃ (ethanol )
Boiling point:	648.7±65.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	-20C
solubility	DMF: 0.2 mg/ml
form	White crystalline solid
pka	1.00±0.40(Predicted)
color	Light yellow to yellow

Safety information for PPQ-102

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.