IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
Synonym(s):IGF-1R Inhibitor II;IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem;N-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401;N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
- CAS NO.:196868-63-0
- Empirical Formula: C18H16ClN3O2
- Molecular Weight: 341.79
- MDL number: MFCD00160558
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:44:47
What is IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea?
The Uses of IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
PQ 401, a novel diarylurea compound, is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) autophosphorylation. Also used as a potential testing agent in the treatment of breast and other IGF-1-sensitive cancers.
What are the applications of Application
PQ401 is an inhibitor of IGF-1R autophosphorylation
Definition
ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines.
Biological Activity
Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .
in vivo
a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1].
storage
Store at +4°C
References
[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79.
Properties of IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
Density | 1.370±0.06 g/cm3 (20 ºC 760 Torr) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO: >10mg/mL |
form | White solid |
color | white |
Safety information for IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
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