PORPHOBILINOGEN

Synonym(s):5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid

CAS NO.：487-90-1
Empirical Formula: C10H14N2O4
Molecular Weight: 226.23
MDL number: MFCD00005224
EINECS: 207-666-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:02

What is PORPHOBILINOGEN?

The Uses of PORPHOBILINOGEN

An intermediate in the biosynthesis of Heme, found in the urine of patients with acute porphyria.

What are the applications of Application

Porphobilinogen is an intermediate in the biosynthesis of heme

Definition

ChEBI: Porphobilinogen is a dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of pyrroles, a dicarboxylic acid and an aralkylamino compound. It is a conjugate acid of a porphobilinogen(1-).

Biochem/physiol Actions

Intermediate in the biosynthesis of heme.

Purification Methods

Porphobilinogen recrystallises as the monohydrate (pink crystals) from dilute NH4 OAc solutions of pH 4, and is dried in vacuo. The hydrochloride monohydrate has m 165-170o(dec) (from dilute HCl). [Jackson & MacDonald Can J Chem 35 715 1957, Westall Nature 170 614 1952, Bogarad J Am Chem Soc 75 3610 1953, Beilstein 22/14 V 210.]

Properties of PORPHOBILINOGEN

Melting point:	174-177℃
Boiling point:	479℃
Density	1.421
Flash point:	243℃
storage temp.	-20°C
solubility	Aqueous Base (Slightly), Acetonitrile (Slightly), DMSO (Slightly)
form	powder
pka	4.22±0.10(Predicted)
color	light yellow to pink
Merck	13,7681
BRN	220051
EPA Substance Registry System	Porphobilinogen (487-90-1)

Safety information for PORPHOBILINOGEN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.