PORPHOBILINOGEN
Synonym(s):5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid
- CAS NO.：487-90-1
- Empirical Formula: C10H14N2O4
- Molecular Weight: 226.23
- MDL number: MFCD00005224
- EINECS: 207-666-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is PORPHOBILINOGEN?
The Uses of PORPHOBILINOGEN
An intermediate in the biosynthesis of Heme, found in the urine of patients with acute porphyria.
What are the applications of Application
Porphobilinogen is an intermediate in the biosynthesis of heme
Definition
ChEBI: Porphobilinogen is a dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of pyrroles, a dicarboxylic acid and an aralkylamino compound. It is a conjugate acid of a porphobilinogen(1-).
Biochem/physiol Actions
Intermediate in the biosynthesis of heme.
Purification Methods
Porphobilinogen recrystallises as the monohydrate (pink crystals) from dilute NH4 OAc solutions of pH 4, and is dried in vacuo. The hydrochloride monohydrate has m 165-170o(dec) (from dilute HCl). [Jackson & MacDonald Can J Chem 35 715 1957, Westall Nature 170 614 1952, Bogarad J Am Chem Soc 75 3610 1953, Beilstein 22/14 V 210.]
Properties of PORPHOBILINOGEN
| Melting point: | 174-177℃ |
| Boiling point: | 479℃ |
| Density | 1.421 |
| Flash point: | 243℃ |
| storage temp. | -20°C |
| solubility | Aqueous Base (Slightly), Acetonitrile (Slightly), DMSO (Slightly) |
| form | powder |
| pka | 4.22±0.10(Predicted) |
| color | light yellow to pink |
| Merck | 13,7681 |
| BRN | 220051 |
| EPA Substance Registry System | Porphobilinogen (487-90-1) |
Safety information for PORPHOBILINOGEN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PORPHOBILINOGEN
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 7-Bromo-1H-indazole N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 4-Hydrazinobenzoic acid Electrolytic Iron Powder Fmoc-Val-Cit-PAB 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 4-HYDROXY BENZYL ALCOHOL 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) S-2-CHLORO PROPIONIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 1-(4-Methylphenylsulfonyl)-1H-1,2,3-benzotriazole 1-(2-Chlorobenzyl)-4-nitro-1H-pyrazole 1-(2-Nitrophenyl)-4-phenylpiperazineRelated products of tetrahydrofuran
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