Poly(hexamethylenebiguanide)hydrochloride

Chemical properties

Colorless to pale yellow solution

Chemical properties

Poly(hexamethylenebiguanide) hydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection. This compound has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect. Although it is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.

The Uses of Poly(hexamethylenebiguanide)hydrochloride

Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes

Preparation

The preparation method of Poly(hexamethylenebiguanide)hydrochloride:By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.

Biological Activity

Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.

Properties and Applications

Polyhexamethylene biguanide hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer. It is a water solution that can be used as a broad spectrum and high efficient disinfectant. It is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic. Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.