piritramide
- CAS NO.:302-41-0
- Empirical Formula: C27H34N4O
- Molecular Weight: 430.59
- EINECS: 206-124-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:44:02
What is piritramide?
Chemical properties
Off-White Low Melting Solid
Originator
Dipidolor ,Janssen W. ,Germany,1969
The Uses of piritramide
Piritramide is a synthetic opioid commonly used in Germany and Austria for the analgesia of pediatric patients.
Background
Piritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting.
Definition
ChEBI: Piritramide is a nitrile.
Manufacturing Process
A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4piperidino-4-piperidinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and recrystallized from 320 parts of acetone, to give 1-(3,3diphenyl-3-cyanopropyl)-4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C.
Therapeutic Function
Analgesic
Metabolism
Not Available
Properties of piritramide
Melting point: | 149-150° |
Boiling point: | 544.82°C (rough estimate) |
Density | 1.0967 (rough estimate) |
refractive index | 1.5900 (estimate) |
storage temp. | Controlled Substance, -20°C Freezer |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 16.19±0.20(Predicted) |
color | White to Pale Beige |
Safety information for piritramide
Computed Descriptors for piritramide
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin E Tubulysin D 2,2-diethoxyethanethioamide 1-(1,1-Difluoroethyl)-2-fluorobenzene 2,2-Difluoropropylamine hydrochloride 2,2-Difluoropropanol Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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