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HomeProduct name listpipazethate

pipazethate

  • CAS NO.:2167-85-3
  • Empirical Formula: C21H25N3O3S
  • Molecular Weight: 399.5065
  • MDL number: MFCD00866844
  • EINECS: 2185088
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
pipazethate Structural

What is pipazethate?

Originator

Theratuss, Squibb ,US ,1962

The Uses of pipazethate

Antitussive.

The Uses of pipazethate

Pipazetate, is a pyridobenzothiazine derivative an antiarrhythmic characteristics. Pipazetate is used as a cough supressant.

Definition

ChEBI: Pipazetate is an aryl sulfide.

Manufacturing Process

8.5 parts of 1-azaphenothiazine carboxylic acid chloride and 14 parts of piperidino-ethoxyethanol were introduced into 100 parts of chlorobenzene and the mixture boiled under reflux for 5 minutes. After cooling off the precipitated hydrochloride salt of piperidino-ethoxyethanol was filtered off on a suction filter. Water was added to the filtrate and the pH thereof adjusted to 5 to 6 with dilute HCl. The aqueous phase was then removed, a caustic soda solution added thereto and then extracted with ether. The ethyl extract was washed with water, then dried with potash and the ether distilled off. 9.4 parts of the piperidino-ethoxy-ethyl ester of 1-azaphenothiazine carboxylic acid were obtained. This product was dissolved in 20 parts of isopropanol and the solution neutralized with isopropanolic HCl. The monohydrochloride which precipitated out after recrystallization from isopropanol had a melting point of 160°C to 161°C.

Therapeutic Function

Antitussive

Properties of pipazethate

Melting point: 50-53°C
storage temp.  Refrigerator
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
color  Off-White

Safety information for pipazethate

Computed Descriptors for pipazethate

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